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Showing posts from September, 2017

Sulfation Revisited, DHEA and Syndecans

Earlier on these series of posts, Sulfation was discussed as being -potentially- important.  Several Algorithmic Runs identified Sulfation and associated Genes as being important, therefore Sulfation required extensive Research to understand its possible involvement (as suggested by Machine Learning).
In [1] we read :

"Sulfation is involved in a variety of biological processes, including detoxification, hormone regulation, molecular recognition, cell signaling, and viral entry into cells.[1] It is among the reactions in phase II drug metabolism, frequently effective in rendering a xenobiotic less active from a pharmacological and toxicological standpoint, but sometimes playing a role in the activation of xenobiotics (e.g. aromatic amines, methyl-substituted polycyclic aromatic hydrocarbons). Another example of biological sulfation is in the synthesis of sulfonated glycosaminoglycans, such as heparin, heparan sulfate, chondroitin sulfate, and dermatan sulfate. Sulfation is also a…

More Genes relevant to Phagocytosis - Apoptosis and the role of Retinoids

In previous posts we presented results that originated from Machine Learning and Network Analysis. These results can be used as hypotheses as to what can be the potential causes behind the Devastating syndromes that are discussed in the first post.
It should be stressed that according to the hypotheses being generated by these methods it appears that there is a combination of factors at play. So far we presented many of these factors such as Bile Acid Homeostasis, Apoptosis of Cells, Endoplasmic Reticulum Stress, The Unfolded Protein Response, Myosins, etc). 
Please see below the following figure which is taken from a paper called "Impaired clearance of apoptotic cells in chronic inflammatory diseases: Therapeutic implications" : [1]

We now look at the same Figure but we annotate with a blue rectangle the Topics presented in this Blog that were selected with Machine Learning and / or Network Analysis. In red rectangles we have topics that were not selected by these methods…